Observations on the Antimony (Urea-Stibamine) Test for Kala-Azar
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چکیده
In the Indian Medical Gazette for June 1927, Chopra, Gupta, and David described a new serum test for kala-azar. These workers observed that when certain organic compounds of antimony were brought in contact with the serum from kala-azar patients in a miniature testtube, a thick flocculent precipitate was formed at the junction of the two; whereas with nonkala-azar sera no such precipitation occurred. This reaction of the kala-azar blood was so characteristic that these observers developed it into a test for the diagnosis of kala-azar. They tried a number of organic compounds of antimony, but showed a preference for urea-stibamine for carrying out this test. Napier (1927) extended these observations to a large number of cases and corroborated the findings of Chopra and his collaborators, but preferred weaker solutions of antimony compounds. As kala-azar
منابع مشابه
On the Toxicity of Some Organic Antimonial Drugs Used for the Treatment of Kala-Azar
are widespread. Some indication of the value of antimony is the fact that without treatment the death rate from kala-azar is over 90 per cent, whereas with treatment in Indian kalaazar it is reduced to below 10 per cent. Although tartar emetic was found of value in the treatment of kala-azar, its considerable toxic effects made it imperative to obtain other derivatives which should be better to...
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